Triple Marker Screen Test

Triple Marker Screen Test: Cost, Procedure, Results And Benefits.

Triple Marker Screen Test


Pregnancy is an important time for any woman. So during this time, special attention needs to be given to the woman as well as the baby growing in the womb. This is the reason that doctors keep an eye on every change that occurs in the woman and the fetus. In such a situation, several types of investigation are recommended. One of these is the triple marker screen test. In this article, we are going to give you many such information related to the triple marker screen test.

In some cases, genetic infarctions are found in the infant after birth. At times, they can also be disabled by the infant mentally. Being a genetic problem increases the chances of pregnancy. A triple marker test is done to get information about this.

What is the triple marker screen test?

The triple marker test is a screen test performed during pregnancy in the second trimester. It is also called the Triple test, Kettering test, or Bart’s test. Although, this is a type of blood test. A triple marker screen test is done to find out if the fetus has any birth defect related diseases like Down syndrome, spinal cord, and brain disorder. Let us know that many people are skeptical about the quadruple and triple marker test. The only difference is that the levels of inhibin A (inhibin A) are measured in the quadruple, whereas in the triple marker test it does not.

Who needs a triple screening test in pregnancy?

In the 12th week, all pregnant women are advised to undergo a double marker test. Triple markers are recommended for pregnant women who cannot get double markers.

What does the triple marker screen test do?

Blood samples are examined in the triple marker screen test. It detects AFP (alpha-fetoprotein), HCG (human chorionic gonadotropin), and estriol levels. Let us know in detail about these three:

AFP (alpha-fetoprotein): It is a protein produced by the fetus. Excess of this protein can cause fetal neural tube defects, stomach problems, or even death in the womb itself. High AFP can also mean that you have more than one fetus in your womb.

HCG (Human Chorionic Gonadotropin): It is a hormone produced by the placenta. High levels of HCG can cause Down syndrome and Edwards syndrome (chromosome related disorders).

Estriol: It is estrogen, which belongs to both the fetus and the placenta. The infant may be at risk of Down syndrome due to low estriol levels. Especially when AFP and HGC levels are also abnormal in the test.

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When is the triple marker screen test done?

This test is done in women who have pregnancy between 15 and 20 weeks. An alternative test for this test is the quadruple marker screen test, which detects a substance called inhibin A.

Levels of alpha-fetoprotein (AFP), human chronic gonadotropin (HSG), and estriol present in the placenta are detected through triple marker tests. However, this test should be done by every woman. These women must undergo a triple marker screen test.

  • Have a family background in genetic problems
  • Age 35 years or more
  • Have had prenatal medication and have side effects
  • Have diabetes and insulin problems
  • In the case of prenatal viral infection
  • The highest risk of exposure to radiation

How to prepare for the test?

It is a common screening test performed by a blood test. Therefore, no special preparation is required before this. It is generally not needed after the double marker.

How is the triple marker test performed?

The triple marker screen test is performed just like any other blood test. Although, this test is done in a hospital, clinic, doctor’s office, or lab. In this process, the experts take blood samples from the arm and send them for testing. Levels of alpha-photoprotein, human chorionic gonadotropin, and estriol are measured during tests in the lab.

Triple Marker Screen Test Procedure

In this test, the mother and child are not at any risk. The triple marker test is performed through a simple blood test. After taking the blood sample, he is sent to the laboratory. Levels of alpha-photoprotein, human chorionic gonadotropin, and estriol are measured during tests in the lab. The report comes within a few days. You then need the help of a doctor to analyze the report.

What are the results of the triple marker test?

If the test results are positive, it means that your baby is more likely to have birth defects. At the same time, the negative report means that the baby growing in the womb is safe.

General Results for Triple Marker Test:

The results of the triple marker test depend on the levels of AFP, hCG, and estriol obtained from the test. These include typical results from women aged 18 to 47, 1.38 to 187.00 IU / mL for AFP, 1.06 to 315 ng / mL for HCG, and 0.25 to 28.5 NML / L for estriol. Here we make it clear that this level can change with each day of pregnancy.

How accurate is the triple test in pregnancy?

We can understand the accuracy of the results of the triple marker screening test in this way:

  • Through this test, 80 out of 100 embryos can be accurately detected whether he has spina bifida or not. It is difficult to detect in 20 embryos.
  • Similarly, 90 out of 100 embryos can be detected or not. In the case of unsafe, the brain and spinal cord of the unborn child are not fully developed.
  • In addition, Down syndrome can be detected in 69 out of 100 embryos. At the same time, it becomes difficult to detect in 31 embryos.

What are the benefits of triple marker testing?

A triple marker test can detect a baby’s Down syndrome (a genetic disorder) or spina bifida. In addition, this test may also indicate the presence of multiple fetuses in pregnancy. If the results of all tests are normal, the chances of having a child with a genetic disorder may be lower and the child may be born without any disease. Through triple marker testing, we get to know related diseases, which we can treat in time.

Are there any risks associated with the triple test?

In the process of the triple marker test, there are no side effects for both the infant and the mother. Since the triple marker screen test is done with a blood test, you may only feel a needle prick while removing the blood. Yes, if the needle is infected, both the mother and the fetus may be at risk of infection. In addition, there is no risk associated with the triple marker screen test in general.

What is the cost of the test?

Its estimated cost can be around 1250 to 4200 rupees. This cost can be more or less depending on the city, doctor, and hospital.

Why the second test after the triple marker test is important?

In the Triple Marker Test, it is often recommended to have additional tests when gene-related differences are revealed. Because, this test is not done for the purpose of treatment but rather, gives indications of potential dangers. The condition of conducting additional tests may vary among women.

You must have known through this article how much the triple marker screen test is necessary for a pregnant woman and a fetus. Also know that by this test, the birth defects occurring in the fetus can be treated and treated in a timely manner. So if you are a pregnant woman, this article may prove beneficial for you.

Read More: Neurodermatitis: Causes, Symptoms, And Home Remedies


Q. What is the normal range of the triple marker test?
A. The levels of triple screen biomarkers range from 1.38 to 187.00 IU / ml for AFP; 1.06 to 315 ng / mL for HCG; And 0.25 to 28.5 nmol / L for uE3.

Q. Is the Triple marker test necessary?
A. A triple marker test is a pre-birth test to check for the chance of birth/hereditary/chromosomal deformities in the unborn child. The triple marker test strategy is suggested for all pregnant women, particularly in the event that they report: a family background of hereditary issues. 35 years or more established.

Q. What if the triple marker test is positive?
A. A triple marker screen test may show possible entanglements with the pregnancy, just as the presence of numerous hatchlings. It assists guardians with planning for birth. In the event that all test outcomes are typical, guardians realize they are more averse to have a hereditary issue.

Q. What if the triple marker test is negative?
A. What Does a Negative Screen Mean? A negative screen result most likely implies that your baby is at okay of creating birth imperfections, for example, neural cylinder abandons, Down disorder, and Trisomy 18. Nonetheless, getting a negative screen doesn’t ensure a typical birth or a fit as a fiddle child.

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